It's Windows XP Pro SP2.
They are trying to save files they opened in Microsoft Word and Excel back to their My Documents folder on the local drive.
To test whether avast was the culprit, I had them right click on the tray icon, and click "Stop On-Access Protection", so I haven't tried just pausing the provider.
I'm sure the sensitivity is set to normal, because I didn't change it, and that is the default value.
The application itself locks up. The mouse still moves, but they are unable to minimize the application, and trying to open another application doesn't seem to work.
(I'm hearing all this information from the customer, and I haven't investigated it myself. I did talk to them on the phone and asked a bunch of questions, but I thought that would be relevant also. Especially in the case of the level of "unresponsiveness" of the PC.)
I hope this helps..