Regarding scheduling a scan, this is a feature available in the Pro version, not the Home.
My experience suggests that scanning is not required very often. I've gone from doing it daily to weekly and now to about every month or two, becaue it is so seldom anything is found. (Suggests the protection in my setup, which is basically Avast, a Hosts file/SpywareBlaster, and a firewall) is pretty good.
Manual scanning is recommended when Avast is first installed, then (in my experience) you can let the on-access protection prevent the nasties getting in.
When you run a manual scan, it is helpful to place an Eicar (simulated virus file) near the beginning of the C:\Windows folder, so it will be detected early. At that poinst you can address the popup, (select "no action", and "don't show me this next time") and that way the drive will be completely scanned, and the results can be addressed.
If you don't do that, the scan will stop at the first detection, awaiting your input. If you've gone to bed with a scan running and see that waiting for you the next morning it's a bit frustrating. Especially if the detection is only 10% in.