Excellent, I like the sound of big hammer time.
Ran the combofix. Got a few messages asking me to run certain things, etc. I clicked yes, agree, etc. to all. Screenshots attached, along with the log at the end.
Before the reboot, combofix closed a whole lot of my windows and this caused some windows errors, asking to send error reports, etc. to which I just selected cancel or close or whatever was appropriate.
Haven't noticed any changes yet other than my windows security centre settings appear to have been changed a bit.
Thanks.