You cannot compare MSE to Avast ...
MSE : Signature based. What happens to malwares that MSE does not detect ? They just go throught ... BTW, MSE is really good for someone with a normal usage of his PC it is light and efficient on widespreads threats (this is definitely true).
Avast! : Signature based, streaming updates, Cloud file reputation, Autosandboxing of suspicious files, more options etc etc ... for free!
So basically, a malware not detected by signature will be detected by Evo or FileRep or autosandboxed ... More prevention oriented.
IMO, both products should be considered as well you can install MSE and forget it run a MBAM scan/week ...
spywar