Hey Chim,
Yes, and no...
I run a lot of the portableapps from my hard drive and so I run into a couple of issues, like you see...
What you want to do is set some file associations, but this can cause problems...it works for some, but not others.
I do use foxit portable - I use open with --> and find Foxitportable.exe this then uses the portable version when opening PDFs...
I can't however do this for browsers for example...
There are a couple of apps in PA.c that can do this, but I haven't used them so can't comment.
Scott
EDIT: Another point, if they are always on the drive, there *may* be problems as I am not sure how windows would handle the drive letter switching - as it does when more drives are plugged in