I don't think because it hasn't been a problem in the past is any guarantee as signatures are constantly added and modified in the generic signatures.
With 12/36 detections I would normally say this is confirmation enough, but virtually all the detections are heuristic (suspicious) or Generic (-gen .gen) there is certainly a case to send it for further analysis.
Send the sample to virus@avast.com zipped and password protected with the password in email body, a link to this topic might help and possible false positive in the subject.
Or you can also add the file to the User Files (File, Add) section of the avast chest (if it isn't already there) where it can do no harm and send it from there (select the file, right click, email to Alwil Software). No need to zip and PW protect when the sample is sent from chest. A copy of the file/s will remain in the original location, so any further action you take can remove that.
I would certainly consider contacting the game maker and point out the VT results URL as some thing is considered suspicious enough to alert in many AVs.