avast! works with multiple smtp/pop servers and can protect as many pop3/smtp server accounts as you want:
1. Configure your email accounts to work without the antivirus and test them.
2. If everything is fine, close all your email clients (programs).
3. Start Menu > All programs > avast antivirus > Mail Protection Wizard
4. Follow the non Outlook/Exchange option (i.e., the second one).
You can choose the supported email programs and select all the accounts
(even the ones created in the future).
5. Configure your email accounts to use avast! as antivirus.
Note: the pop/smtp default servers are just the 'default' ones. They would be used to send files to Alwil Software (for virus analysis, for instance) and in special email accounts configurated to use 'default' servers.
Hope this helps.
More information here:
http://forum.avast.com/index.php?board=9;action=display;threadid=4818;start=msg34754#msg34754And about manual configuration, see 'FAQ' on my signature (browse until you find it...) or 'Settings' in [MailScanner] Section.