OK, I'll say some more. There's a sufficient number of legit sites that carry Great Owl. PNY is not supposed to distribute malware, so yes, you can trust Great Owl. I don't know how good it really is.
Avast inhibits Great Owl either through its filesystem shield or (more likely in my opinion) behaviour shield. Vicky: can you mark Great Owl as a trusted process in behaviour shield? Open Avast user interface > Realtime Shields > Behaviour shield (that is with an U, avast, we are not in America!) > Expert settings > Trusted processes > Add > browse to Great Owl and select its executable.
If this does not help, you could try the same for Filesystem shield.
Best Regards,