Restarted my computer and on the bottom of the IE10 page it showed "M86 secure browsing isn't compatible with enhanced protected mode and has been disabled."
Yes some addons are not compatible since they are 32 bit applications and the Enhanced Protection Mode forces IE 10 to run completely in 64 bit on a 64 bit system. Without EPM turned on the browser runs as a 64 bit core but all of the tabs run as 32 bit for greater compatibility. Since M86 comes into play on all web pages you will probably have to turn off the Enhanced Protection if you want to keep using that addon. In the future there will probably be an update to the browser, or M86, or both that will allow it to run in Enhanced mode.
My personal opinion would be that the greater security of the Enhanced mode, especially in Win 8, is worth keeping more than that addon is. Some may not agree however. M86 is really just another form of WebRep. I tried it and found it so slow that I was clicking links in my Google searches long before the rating icons ever showed up. I got rid of it mainly because of that.