Personally I wouldn't use a "automatic cleaner", as I've not had much luck with them. If you choose to, Vlk's suggestion remedies the threat of deleting the _avast4_sub folder. To me Avast! takes priority over a auto-clean utility. The time taken in setting up, configuring exclusions with these cleaners may be better spent ; as Eddy suggested, in cleaning manually .
I've tried a few :BeClean, CCleaner, and shredded them after- wards as they didn't do what I wanted. If I wanted to delete shortcuts I wouldn't have created them,... plus other issues put me off using these apps.
By the way the latest release of Avast! 4.6.623 has sped up both Xp and win98SE for me . For a while there with the previous version it was like I'd forgotten to release the handbrake. Real sludgy browsing! It's a relief to have good ol' Avast! running proper again. Thanks Vik , and team for sorting it out.