First line of defence is YOU, not avast!, Malwarebytes, or any other malicious file protection/remover or program.
A review of posts here reveals a lot of adware cr*p, but not any real serious infections. Now, I'm assuming Malwarebytes is finding stuff related to Advanced Fix, so that is to be expected, if so. It's there because you likely put it there. Stop doing that. Free programs are not really free, as you have seen.
If you can, avoid rebooting your system until essexboy comes back in, and do not make any more changes to your system without checking with him first. This would include downloading and running a program similar to Advanced Fix. Makes the job of cleaning your system much easier and you will get there much faster.
Please post the mbam log after it is finished, and a screenshot of the avast! threat detection will help.
Wait for essexboy to come back.