Thank-you very much for this advice, I will certainly make sure I clean my S&D quarantine archive every other month or so.
I have a number of security software installed on my system which I only use for on-demand scanning, I disable the resident features of all security software (apart from avast! Free Antivirus of course). I use Malwarebytes Anti-Malware, SUPERAntiSpyware Free Addition, Kaspersky's Anti-Rootkit Scanner, Emisoft Anti-Malware and Spybot: Search & Destroy ALL for on-demand scans to ensure my computer is as clean as possible of threats. (If you have any advice regarding my setup, please let me know.
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In regards to your question about my use of AdwCleaner, I ran a scan one day using Spybot: Search & Destroy and the outcome showed a result for Delta.Toolbar. I then ran a second scan to ensure the threats had been removed again, finding out Delta.Toolbar had not been completely removed as a result for this was still shown. Because of this, I did a bit of research on Google and a number of various threads on different forums recommended running a scan of AdwCleaner.
I downloaded and ran a scan with AdwCleaner, to find that only a few traces of annoying toolbars and cookies were found. That is how I have some results shown after my avast! Free Antivirus full scan.
After some more research, I then found out that right-clicking the scan button within the Spybot: S & D software and running the scan as administrator allowed these stubborn threats/PUPs to be removed!
I hope you understand.