A "PUP" is just that...a potential unwanted process. A "PUP" could be either good or bad. The keyword is "potential".
Given the results of multiple scanners is the reason I would consider the file unsafe.
Irregardless of the "avast" result. Knowing that not one single antivirus has one hundred percent detection rate
could mean that avast might have missed something. avast does have a detection rate of over ninety eight percent.
There is still that little over one percent that still gets through.
That said I still put a huge amount of trust on avast for my primary protection.
Here is the latest chart from
AV-Comparatives.
avast is second from the left. Not bad at all.