Many thanks to craigb and DavidR for your replies. I did not even know I had that file, until I was trying to track down what crashed some of my progs. I have only had instup.exe disabled for a couple of days now and my Avast is "All Good", but "Avast Service" as well as "Avast Antivirus" are still enabled. I have never had any kind of problems with Avast, but as it seems to crash the progs whether en- or disabled, it looks like I need to find another AV.
P.S. and as forecast by DavidR, I cannot delete the file itself.