@ pctech & waicookie
You don't say what avast version you are using or what MS Office version ?
Depending on what avast version you are using you can do a 'Restore and add to exclusions' from the virus chest, but you have to be very sure they aren't infected when taking action like this.
I guess this is a very old version of MS Office, so the files probably aren't digitally signed and would score lowly on the file reputation side.
I had this happen for office 9t on my XP Pro system, it was a case of adding an exclusion for the excel.exe and winword.exe files in what was the old autosandbox process, now the DeepScreen.
What concerns me is your saying it is also alerting on other files:
If you can give some samples of the location, file name and malware name given on the detection.