That is where avast sends files that it is going to scan and or unpack to scan.
So there must be some massive file being unpacked, when files have been scanned successfully avast would remove them from that folder.
There could be an issue with other security based applications blocking avast from removing it from the _avast_ folder. What other security software do you have installed, anti-spyware, firewall, etc. ?
Have (or did) you another Anti-Virus installed in this system, if so what was it and how did you get rid of it ?