Thank you igor, it's something I want to be as secure as possible without sacrificing usability, I've had it disabled for awhile now without any issues, although I did one time get careless online and hit a trojan, thankfully Avast still detected and stopped it, so I'm thinking it still is functioning well enough as an Antivirus without it.
So correct me if I'm wrong Virtualization, just creates a way to prevent the Malware from disabling the Antivirus. Any signs to look for to see if Avast has ever been compromised?