The message window closes, but in the bottom right corner of OE6 there is a 'sending mail' notification. If you click on this it opens to show the whole dialog box with a status bar. The bar goes to 99% immediately and then sits there for the 4 minutes until it eventually goes.
Yes, the 512kb is the download, 128kb up, but I wanted to show that it takes at least 4 times as long to send when the message is scanned (1 minute to 4 minutes).
I have been able to replicate this on EVERY PC. Different SMTP servers, ISP's, hardware and OS. It's always the same. I'm assuming the scanning of the attachment is taking a long time, though all the Avast processes are idle during sending.
Let me know if you want me to try anything else.