yeah, that's old!
I added an edit to my previous post, maybe you can shed some light on this question. But if you are running an old COMODO, you probably don't have autosandbox. Anyways, question is:
EDIT: I suppose I should also ask: how will Avast hardened/aggressive react to a process that COMODO puts in autosandbox? Will it be automatically allowed, because it is treated as a child process of COMODO?
If so, I would think that autosandbox is useless, and HIPS only should be enabled.