I was actually going to mention the same thing about iObit, but you beat me to it lol
Some others I would suggest are Malwarebytes Anti-Malware, SUPERAntispyware, and spybot Search & Destroy. You can also use things like CCleaner to help optimize, and clean your system, much in the same way that Advanced System Care does (Minus the speed hacks)
Defragging as often as you say you do has the potential to wear out the hard drive sooner rather than later. I usually recommend running defrag about once a month as an average.
Advanced System Care, and Malware Fighter, etc from iObit has a high potential to be the cause of your problem. I've had many problems with their software to the point that they are unreliable, and suspicious, especially where their system optimizations, and registry cleaning are concerned. My recommendation to you is to remove their software, and get yourself some that is more reputable, and reliable. iObit's software has destroyed my windows install more than once, both free, and paid versions.