The .ASI doesn't seem malicious at first glance, but further analysis reveals otherwise as per the thread zzcool linked to.
Loading .ASI libriaries are a common practice amongst Grand Theft Auto modders for the past decade, even long after Rockstar discontinued support for the Miles Sound System. Besides natively-compiled ones, scripts written in .NET are used especially with newer games in lieu of writing gameplay logic using the engine's scripting language.
I know not everyone here's arsed to shell out $60 to buy a game just to isolate and analyse viruses using said applications as vectors, but given the recent rise in gaming-related threats these days I'm sure it wouldn't hurt to run GTA V on a VM. 'Sides, some of the folks who posted on the linked thread did do their own sleuthing, which should be a starting point.