Same deal with me, starting with 2223 and now 2225. Since 2225 came out so quickly after 2223, I figured it was a fix for this (not). Win XP, Outlook 2000. Not only right-click gone (as in marking an item read or unread, etc.), but double-clicking on an existing Calendar event produced error (Can't open; Msg Interface returned unknown error). But strangely, not all calendar items. Disabling all shields, then opening Outlook, does not help. Pretty sure this is Avast; only updates I've done on three different machines.