The engine on VirusTotal is basically the same as the Windows desktop/server engine.
The difference may be in the particular version, however. The online scanners are not updated during the ordinary program updates, but rather receive a special version of the program from time to time (I am talking about avast! right now, don't know how other products work). So, sometimes the engine might be slightly older than the one publically available, sometimes also slightly newer. While the same virus database is used everywhere, newer versions of the scanning engine may have improved unpacking capabilities, which may affect the detection as well.
In this particular care, you can see that the virus was detected inside of an Upack-compressed executable. The engine on VirusTotal is probably slightly older than your desktop one - and it's probably not able to unpack this particular version of Upack (and the virus database currently doesn't contain the signature for the compressed file itself).