Few weeks back, I bought a new laptop with Windows 10. Though I am familiar with it, but there's still lot to learn from Windows 10
. As per your question, I also did some experimenting with my antivirus Trend Micro and Windows Defender (with limited periodic scanning enabled). I turned it on for couple of hours, but I haven't seen any problems or issue or conflicts. I am now using Zemana Antimalware (trail version=27 days remaining) with Trend Micro and WD turned completely off (Limited scanning disabled).
I am using now Trend Micro, MBAM Free, and Zemana Antimalware. I have used SuperAntiSpyware (Lifetime license) on my previous malfunction laptop Windows 7), but I won't download it again, because I think I have used 3 license of that program (lifetime license can only be used on 3 computers). There's also SuperAntiSpyware Free, but I don't think I will not install that one on my Windows 10. I may think to buy the 3 year license for Zemana Antimalware, Zemana Antimalware is a pretty awesome antimalware.