Is this when you enter the registration key ?
Is the file C:\Program Files\Alwil Software\Avast4\ashUInt.dll present ?
Try a repair of avast. Add Remove programs, select 'avast! Anti-Virus,' click the Change/Remove button and scroll down to Repair, click next and follow. You need to be on-line to do this.
If that doesn't work try, uninstall, reboot, install, reboot.
How are you trying to enter the registration key ?
- cut and paste, ensure there are no spaces after the key.
- typing in key, try a cut and paste to avoid error in input.