It looks like something is accessing the thunderbird profile whether that is because of an email check or something (sorry I don't use thunderbird), why I have no idea. Do you have any form of automatic email checking, etc. ?
The first line in the image seems strange also, as that would appear to be something accessing the javascript file to close all thunderbird windows
How long does this last for a few seconds, minutes, longer ?
Is there any firewall activity in the firewall logs for the same times ?
What is the Sensitivity of Standard Shield, Normal (the default) or High ?