Sorry I can't help you with ZA and what you should expect I haven't used it in over 3 years and that was the free version.
Reconfiguring wouldn't change any detections, unless when they were detected you selected ignore if that option existed but, you should only choose that option if you absolutely know the detection is incorrect.
Personally I prefer to use other dedicated anti-spyware products in an on-demand scan function, rather than have a unknown bolt-on/plug-in solution incorporated in my firewall (as I said let it get on with being a firewall). This way I update the signatures and run a weekly scan or by monitoring the << Updates >> Topic on the General forum you can see when updates are reported for your anti-spyware, I download the signature update and then I run a scan.
Now if something is detected that previously hasn't been I don't take it at face value, I check what is being detected and investigate, google, etc. only if what is being detected is serious, not tracking cookies, etc. Before I would allow a deletion, file or registry entry I check and double check. If it isn't serious and/or I'm not convinced it is a positive detection then I ignore it and frequently the following week a false positive detection has been corrected and it isn't detected again.