Hi 4lakewylie,
Can you please:
1.) Run following command in cmd.exe (via Start -> Run -> "cmd") and provide its output?
tree /F "%LOCALAPPDATA%\Avast Software\APM"
2.) Run regedit.exe (via Start -> Run -> "regedit") and navigate to HKEY_CURRENT_USER\Software\AVAST Software\Avast\PRIVATE. There should be a key called PAMVaultLocation and I'll need to know its value. In case you get access error, please disable Avast self-defense module first in Avast's settings (Troubleshooting section).
In your case, I suspect you have multiple vaults and the application chose the wrong one to work with at the startup. The info above will help me to figure out if you have multiple vaults and how is the selection process set up.
Dan