Have (or did) you have another AV installed in this system, if so what and how did you get rid of it ?
Try a repair of avast. Add Remove programs, select 'avast! Anti-Virus,' click the Change/Remove button and scroll down to Repair, click next and follow. You need to be on-line to do this.
If that doesn't work try, uninstall, reboot, install, reboot.