Well considering that the original poster reports actskn45.ocx (as in the title) and not actskn4.ocx, this doesn't seem relevant.
actskn4.ocx is also installed by avast as I mentioned for the use of skins in avast.
The one in my system32 folder has an MD5 of 99825c8aed2fa0ac76aa0fad770f44c1 and SHA1 of 6d19de49d974f8645147d3001fe2cda73ed17742 neither of which match that of the one you uploaded to VirusTotal. So the ony thing in common they have is a file name.
So, as Bob said in your other topic, where did you get this sample you uploaded as it clearly isn't the one that avast loads for using the skins.
This is the one avast loaded and I uploaded to virustotal.