Virus total doesn't run the full set of avast tools, essentially it is running an on-demand scan, whereas a real-time on-access scan checks more aspects (behaviour, etc.)
Since you didn't attach a screenshot of the avast alert we haven't much to work with.
Is this an IOBIT security based program ?
It could well be conflicting or doing something that wouldn't ordinarily be done in a non-security based program.