Generally I tend to leave the registry alone unless I have an indication something is actually wrong (some will find it hard to know if something is wrong). Whatever reg cleaner you use ensure that it has a backup function so you can restore the registry entries removed should there be a problem.
I have a little app called RegSeeker (fairly old) that I used to run frequently on my XP Pro system (don't know if it is win10 compatible), but it didn't find much (certainly not that they were likely to be a problem) so I haven't used it for some time. I use the portable version so no install.
It seems that it is also compatible up to and including win10
http://www.hoverdesk.net/I just ran it and considering I haven't used for some considerable time there weren't many issues (88), none that I really consider serious, mostly it was 'File or Path does not exist.'