Generally users of screenreaders navigate through computer by pressing the keystrokes, such as tab, shift+tab, and arrow keys, or key shortcuts.
As I heard, Avast for jaws screenreader is accessible, but for most of the blind people it is expensive. In Poland, it costs 4000 zlots. I have:
Os - Windows 10 professional x64 build 19.09
Earlier I had windows defender security center.
Thank you
PS. I think, that the best solution for all screenreaders will be to create avast products as a web application.