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File into Chest (Quarentine) are safe to stay there.
You can let them there for 2 or 3 weeks, rescan them into Chest (right click the file) and be sure they're infected.
Then you can delete them...
This is a precaution because system files (necessary to boot and use the computer) or false positives (clean files that was wrong detected as being infected) could happen from time to time and it's safer not to delete the file, but send them to Chest for further analysis.