I think this issue is getting worse. It is intermittent, but stills occurs too often.
I run two instances of Thunderbird, each using a different profile (but the same emails). One profile does not download messages, it only gets headers (so I can get rid of the junk before downloading messages). It seems as though when the problem occurs T-bird does it's thing and Avast just never gets back so T-bird times out. Also, when I do get a header and I want to have that profile download the message and I click on the command, sometimes it works and other times nothing happens.
When the issue occurs with one instance of Thunderbird, it also is problematic with the other instance.
With mail shield off, everything works at lightening speed.
At this point, I feel that the Mail Shield is unusable.