It could well be that it isn't something that might be detected by what are more anti-virus scanners. There are other malware scanners,
http://www.spywareguide.com/onlinescan.php,
http://www.spywareinfo.com/xscan.php.
Also seeing your initial post again and the image showing it isn't in a system folder but is a running process "TBA08C.exe, system, 2592K" you need to kill the running process before trying to remove the file otherwise windows will protect it. You will also need to remove the start-up entry for it.
Does ccleaner not remove it when you empty the temp folders ?
If not you may need to uncheck the option that doesn't delete items in temp folders for 48 hours. Or you could manually clean the temp folders. If it keeps coming back you have something else on the system that is restoring it, see the programs listed below.
S&D is getting really long in the tooth and I haven't detected anything with it for a very long time now and I uninstalled it, fed up of the large updates and poor connections to update servers.
If you haven't already got this software (freeware), download, install, update and run it, preferably in safe mode.
1.
Ewido, a.k.a. avg anti-spyware If using winXP. or
a-Squared free if using win98/ME.
2.
Ad-Aware SE Personal Edition 3.
Spywareblaster Don't install this until you are clean.