- offers offline (no internet access) virus definition updates?
Yes (in the sense that you download an executable from the Internet, transport it to the target machine in any way you like, and start it there to update the definitions).
- offers offline (no internet access) subscription renewal?
No, in my opinion - at least under ordinary circumstances (if you purchased thousands of licenses, it might be doable somehow... but don't take my word for granted here). Or, maybe some of the resellers might offer something like that.
- How are exceptions handled? (Is it scriptable or can it be done via configuration file? It is preferable to avoid manual exception setup)
What exactly do you mean by "exceptions"?
- Can installation be scripted for imaging and deployment purposes?
Yes, it's possible to create so called "silent installation" with specified options. Or, you can use managed clients together with ADNM - deploy the program remotely.