Comparison of time taken to run 'OpenOffice.org Writer 2.2' from fresh boot with various AV (all free for home use except CA). Deliberately used slow PC (SIS630, Celeron 850mhz, 256MB RAM) so as to clearly see differences. All AV at default settings. Each timed twice (reboot in between) and times averaged. (They were the same or very close anyway.)
Comodo AV 2.0 Beta, 103 seconds
PC Tools AV 3.1, 40 seconds
Spyware Terminator with CLAMAV plugin, 37 seconds
PC Tools AV 4.0.0.18 (beta), 34 seconds
Avast! 4.7 , 33 seconds
CA Antivirus 8.4, 29 seconds
AVG (Antivirus) 7.5 , 27 seconds
AOL Active Virus Shield, 26 seconds No Longer Available
Avira PEC, 25 seconds
Avast! 4.7.1098, 24 seconds
NO AV installed, 20 seconds