I used Avast for a couple years with XP. Last Jan I purchased a new Gateway GT5412 with Vista Home Premium and loaded avast! 4.7.1085 after completely uninstalling McAfee. Everything went fine for a while then my machine began to slow down real bad. First it was when refreshing websites, and eventually even MicroSoft programs I have loaded on the machine started to slow and take forever to load. I'm talking 30-45 seconds even up to a minute just to load a Word file. Even "control/Alt delete" took forever to activate. I did virus scans, system restore, you name it, I tried everything. To make a long story short, I finally tried turning off Windows firewall, no help. I turned off defender, no help. But as soon as I turned off Avast my machine worked fine. I uninstalled Avast TOTALLY and reinstalled it, hoping I had somehow corrupted a file. It was OK for the first day so I loaded the Avast updates and then it started all over again. I'm through fighting with it. I uninstalled it again and my machine is like a new computer with absolutely NO PROBLEMS. I loaded another antivirus program (Win Live OneCare) and finally I am trouble free. I believe the problem was a conflict between one of the Avast updates and Vista, or maybe the firewall or defender, but I can't be sure. I post this simply for Gen info.