Well the D+ can be a powerful tool. It's a type of HIPS.
You could maybe try another HIPS program if you uninstall Comodo, but frankly, with MBAM pro active also, I don't think it's necessary. Two residents - it will possibly slow your system slightly, I don't know, but the combo reportedly works well, and what one misses (if anything) the other is likely to catch.
What I would recommend is to use Firefox with the Noscript add-on. Noscript basically makes Firefox a very secure browser. (Without it it's no better nor worse than any other). Noscript will stop drive-by downloads dead. They won't even get from an infected page to your browser.