I was playing WoW as usualy, then got popup from Avast (4.7 back then) to reboot computer as new version (4.8 ) was installed. Turned off WoW, rebooted... and hell started. System as such worked very good, but the moment I started WoW (and so far only WoW, other games seems to work good) - I couldn't play it anymore. My keyboard/mouse was lagging constantly (writting anything to chat window was cousing ~1sec delay before each letter appeared, pressing a couple of times forward button only coused my character to run forward by itself for a couple of seconds without mouse/keyboard reacting at all, etc.).
I uninstalled Avast - zero problems. Installed 4.8 again - same problem. I checked on another computer - again, installing Avast 4.8 started to couse this sort of lags in WoW, making it unplayable. Lowering wow.exe priority in task manager to below normal was fixing most of the lags, but at times those still were back. I've changed Avast back to 4.7 and problem vanished.
Now, my system is WindowsXP SP2 (32bit) - all updates installed, A64 3000+, 1GB RAM, Avast settings on standard. And stopping all providers did not help either, only full uninstallation helps.