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Generally SpywareDoctor on-demand has a greater detection rate than Spybot.But Spybot allows immunization.Why don't you keep both?
But immunization, I think, will fill your hosts file with some 18000+ entries and thus will practically negate hosts main purpose - speeding up the web browsing...
but when i install spybot,my pc gets slow on its start-up! :'(how can i improve my start-up speed?