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All OK now.
Not sure what caused the problem, but suspect it might have been a Vista update (MS Malicious Software Removal Tool) that was installed just prior to the problem with Avast.
DavidR: Thanks for your reply. Tried "Repair" with no success. Tried to uninstall but Vista and/or Avast would not allow this. Dowloaded ASWclear.exe from Avast site which allowed me to uninstall Avast. Then downloaded Avast (nearly 2 hours on dialup!) and reinstalled. All OK now. Not sure what caused the problem, but suspect it might have been a Vista update (MS Malicious Software Removal Tool) that was installed just prior to the problem with Avast.