Avast detects it by the On-Access scanner a few minutes on start up once a day.
Again I find this strange as this should be a windows protected area, the file names are changed from the original, though I was able to place a file in there in a little test. I have system restore disabled and I also have the view hidden system files and folders option enabled, so I don't know if that might have anything to do with being able to do this.
What is the infected file name, where was it found e.g. (C:\windows\system32\infected-file-name.xxx) ?
Check the avast! Log Viewer (right click the avast 'a' icon), Warning section, this contains information on all avast detections.