SpywareBlaster does not run it just sets some CLSID ActiveX settings that prevent known malware sites from doing their nasty stuff.
Spybot S&D runs just fine with it and it adds a few more CLSIDs if you do the Immunize.
E5200 2.5GHZ, 4GB RAM, 320GB HD, Windows 7 Home Premium 64bit, avast! V9.0 Free, IE10
P4 2.8GHZ, 1.5GB RAM, 40GB HD, XP Pro SP3 32bit, avast! V9.0 Free, Google Chrome
with hpHosts, MVPS HOSTS files, SpeedFan, WinPatrol PLUS