While there isn't a browser that's 100% safe, I think Opera is the safest browser.

Opera is the friendliest, easiest browser to use. It's a delight to surf with Opera.
I've never used Chrome, but Opera is the fastest browser I've used. K-Meleon is very fast, but suffers from many of FF's short comings.
Of all the browsers I've used, the one I liked the least was Safari.
The Linux browser I liked best is Konqueror. (I was never able to try Opera on Linux.)