What version of avast are you using, 4.8.1229 is the latest (you say you have the latest but didn't confirm the version) ?
What other security software do you have installed ?
Try a repair of avast. Add Remove programs, select 'avast! Anti-Virus,' click the Change/Remove button and scroll down to Repair, click next and follow.
If that doesn't work try, uninstall, reboot, install, reboot.