davidr how can i delete it from my start up?
Well I thought there was an option by right clicking the entry where you could select delete, however, on checking with XP Pro SP3 that doesn't seem to be available any longer. So I don't know if that is also the case with your OS.
If you uncheck the option it won't try to run it, so that empty/disabled run command would still be there but you wouldn't have to worry about it. Unless you are saying that when you go back to msconfig it is checked again ?
If you ran hijack this you would see this registry entry and you could completely remove it from there.
There is no rush to delete anything from quarantine, assuming it is as good as the avast chest, but in this case when we have positively identified the file as malicious it could also be deleted.
Your image doesn't show anything about tipguard.exe (the whole point in question from your post, reply #5) so I still don't have an answer if you have physically checked your system to ensure it has gone