Well, ppl disabling UAC (those dreaded annnoying and god knows what else popups) are on their own when they get pwned by malware.
No one forces you to disable that like no one disables car airbags just because it might destroy your hair styling when you crash or not use seatbelts because they slightly limit your movement in car. If you crash and die it's your fault. Same with UAC.
I'm a computer veterean (i could say) and UAC doesn't bother me at all. In fact it saved me quite some times from doing something stupid (like accidentally running malware that was suppose to be moved to quarantine or submitted to AV vendors).
I just clicked Cancel. On XP i'd be already looking through files and registry to clean the mess...
Also UAC keeps system clean for longer because it doesn't allow all the junk and every program to modify system settings like they wish.
Even if you give them admin rights through "Run as administrator" they are treated more strictly internally by OS.