I am comfortable running DEP always on, whatever workarounds needed, I will do it just for that extra ounce of protection. As of now I run my XPx64 with LUA, SuRun, DEP full and Avast and use Opera for browsing, hopefully that would keep it clean for me. Yesterday while trying to install new Realtek sound drivers DEP blocked it. I turned off DEP temporarily and installed the update and then turned DEP back on for full protection. A minor inconvenience for protection well worth it.